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The copper complex itself is not optional decoration: the copper ion is what activates the receptor signaling at fibroblast surfaces

Another investigation using male rat liver and BRL-3 A cell models indicated that exposure to copper oxide nanoparticles led to ROS-induced oxidative stress that in turn activated endoplasmic reticulum stress, resulting in apoptosis [97]

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*Correspondence: Liping Qu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers